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CAS 63696-98-0

Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate

Codes: Tenofovir disoproxil phosphate-034

Application context (from source-drug indications)

HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate

Source drugs (routes using this intermediate)

DrugTierExpiry
Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateTier B — Position early-
Tenofovir disoproxil phosphateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate
Tenofovir disoproxil phosphateOptimised routesteps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate

Intermediates available on this site

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