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CAS 638-45-9
1-iodohexane1-Iodohexane
Codes: LUSU-003, Perfluorohexyloctane-008, ORLI-030
Application context (from source-drug indications)
ThrombocytopeniaLusutrombopagDry eye diseasePerfluorohexyloctaneDry eye syndromePerfluorohexyloctane睑板腺功能障碍PerfluorohexyloctaneObesityOrlistatI型高脂蛋白血症OrlistatHypertriglyceridaemiaOrlistat女性不孕OrlistatDiabetesOrlistatObstructive sleep apnoea syndromeOrlistat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lusutrombopag | Tier C — Watch / trade | 2031 |
| Perfluorohexyloctane | Tier C — Watch / trade | - |
| Orlistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(3-bromo-2-methoxyphenyl)ethanone→(S)-1-(3-bromo-2-methoxyphenyl)ethanol→1-iodohexane→(S)-1-bromo-3-(1-(hexyloxy)ethyl)-2-methoxybenzene→2-chloro-N-methoxy-N-methylacetamide→(S)-2-chloro-1-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)ethanone→thiourea→(S)-4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-amine→(E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid→(S,E)-ethyl 3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylate→3,5-dichloro-4-formylbenzoic acid→ethyl 2-(diethoxyphosphoryl)propanoate
1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane→2-(Perfluorohexyl)ethylmagnesium chloride→1-Iodohexane→Chlorido(hexyl)magnesium
ethyl dodecanoate→N,O-dimethylhydroxylamine hydrochloride→N-methoxy-N-methyldodecanamide→prop-1-yn-1-ylmagnesium bromide→pentadec-2-yn-4-one→(S)-pentadec-2-yn-4-ol→(S)-pentadec-1-yn-4-ol→(S)-tert-butyldimethyl(pentadec-1-yn-4-yloxy)silane→1-iodohexane→(S)-tert-butyl(henicos-7-yn-10-yloxy)dimethylsilane→(S)-henicos-7-yn-10-ol→(S,Z)-henicos-7-en-10-ol→(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-ol→(2R,3S)-2-hexyl-3-((S)-2-(methoxymethoxy)tridecyl)oxirane→(3S,4S)-3-hexyl-4-((S)-2-(methoxymethoxy)tridecyl)oxetan-2-one→ethane-1,2-dithiol→(3S,4S)-3-hexyl-4-((S)-2-hydroxytridecyl)oxetan-2-one→(S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanoic acid→(S)-(S)-1-((2S,3S)-3-hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-(((benzyloxy)carbonyl)amino)-4-methylpentanoate→acetic formic anhydride
(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one→(S)-2-formamido-4-methylpentanoic acid→1-iodohexane→dodecanal→ethynyltrimethylsilane→1-(trimethylsilyl)tetradec-1-yn-3-ol→tetradec-1-yn-3-ol→(S)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole→(R)-tetradec-1-yn-3-ol→(R)-1-methoxy-4-((tetradec-1-yn-3-yloxy)methyl)benzene→benzo[d][1,3,2]dioxaborole→(R)-3-((4-methoxybenzyl)oxy)tetradecanal→((1-(benzyloxy)vinyl)oxy)(tert-butyl)dimethylsilane→(3S,5R)-benzyl 3-hydroxy-5-((4-methoxybenzyl)oxy)hexadecanoate→(2S,3S,5R)-benzyl 2-hexyl-3-hydroxy-5-((4-methoxybenzyl)oxy)hexadecanoate→(2S,3S,5R)-2-hexyl-3-hydroxy-5-((4-methoxybenzyl)oxy)hexadecanoic acid→2-methyl-6-nitrobenzoic anhydride→(3S,4S)-3-hexyl-4-((R)-2-((4-methoxybenzyl)oxy)tridecyl)oxetan-2-one
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