CAS 64-18-6

Formic acidN-Methylformamide-001

Codes: (II)91353-6-a, (III)122568-3-a, AZAC-010

Application context (from source-drug indications)

Back painDiclofenac Sodium/Eperisone HydrochlorideAttention deficit hyperactivity disorderClonidine Hydrochloride (Tris Pharma)HypertensionClonidine Hydrochloride (Tris Pharma)OsteoarthritisDiclofenac SodiumRheumatoid arthritisDiclofenac SodiumAnkylosing spondylitisDiclofenac SodiumCommon bile duct diseaseDiclofenac SodiumDental pulp diseaseDiclofenac SodiumArthritisDiclofenac Sodium幼年型粒单核细胞白血病AzacitidineAcute myeloid leukaemiaAzacitidineMyelodysplastic syndromeAzacitidineChronic myeloid leukaemiaAzacitidineChronic myelomonocytic leukaemiaAzacitidine脑性瘫痪Azacitidine

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Diclofenac Sodium/Eperisone Hydrochloride	Tier C — Watch / trade	-
Clonidine Hydrochloride (Tris Pharma)	Tier C — Watch / trade	-
Diclofenac Sodium	Tier C — Watch / trade	-
Azacitidine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 3total yield: /

2-Chlorobenzyl chloride→1-(Bromomethyl)-2-chlorobenzene→Formic acid→(2-Chlorophenyl)acetic acid→1-Chloranyl-2-methylbenzene→2,6-Dichloroaniline→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid

Clonidine Hydrochloride (Tris Pharma)Optimised routesteps: 4total yield: /

1-Chloro-2-nitrobenzene→N-(2-chlorophenyl)hydroxylamine→Formic acid→N-(2-Chlorophenyl)-N-hydroxyformamide→2,6-Dichloroaniline→N-(2,6-Dichlorophenyl)formamide→1,2-Diaminoethane

Diclofenac SodiumOptimised routesteps: 3total yield: /

AzacitidineOptimised routesteps: 5total yield: 101 g

4-amino-1,3,5-triazin-2(1H)-one→N-(trimethylsilyl)-4-((trimethylsilyl)oxy)-1,3,5-triazin-2-amine→(2S,3R,4R,5R)-5-(acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate→AZAC-009→N-Methylformamide-001→1-(diaminomethylene)urea→(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

Intermediates available on this site

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