CAS 641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Codes: RADO-006, RADO-010

Application context (from source-drug indications)

Chronic myeloid leukaemiaRadotinib DihydrochloridePhiladelphia chromosomeRadotinib DihydrochlorideChronic-phase myeloid leukaemiaRadotinib DihydrochlorideMyeloid leukaemiaRadotinib DihydrochlorideParkinson's diseaseRadotinib DihydrochlorideLeukaemiaRadotinib Dihydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Radotinib Dihydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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Radotinib DihydrochlorideOriginator routesteps: 5total yield: /

ethyl 3-amino-4-methylbenzoate→ethyl 3-guanidino-4-methylbenzoate nitrate→(E)-3-(dimethylamino)-1-(pyrazin-2-yl)prop-2-en-1-one→ethyl 4-methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoate→4-methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoic acid→3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline→3-bromo-5-(trifluoromethyl)aniline→4-methyl-1H-imidazole

Radotinib DihydrochlorideOptimised routesteps: 1total yield: 18.7 g

ethyl 4-methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoate→3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Pharmaceutical Intermediates	On request	On request	On request	—

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