← Back to patent-cliff list
CAS 64920-29-2
Ethyl 2-oxo-4-phenylbutyrate2-Oxo-4-phenylbutyric acid ethyl ester
Codes: Enalapril-001, Enalapril-026
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilEssential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Enalapril Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethyl 2-oxo-4-phenylbutyrate→L-Alanyl-L-proline
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 6total yield: 174mg(Enalapril-033)
(2-Bromoethyl)benzene→Bromido(2-phenylethyl)magnesium→Oxalic acid diethyl diester→2-Oxo-4-phenylbutyric acid ethyl ester→4,5-Ditritium-L-proline→L-Alanine→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine→N-Hydroxysuccinimide→Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline→(2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline
L-Alanine→N-Boc-2(S)-aminopropanoic acid→(4R)-4-Amino-1,3-oxazolidine-2,5-dione→Methyl L-prolinate hydrogen chloride→Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate→N-(tert-Butoxycarbonyl)-L-alanyl-L-proline→L-Proline→L-Alanyl-L-proline→2-Oxo-4-phenylbutyric acid ethyl ester→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
Ethyl 2-oxo-4-phenylbutyrate→L-Alanyl-L-proline
(2-Bromoethyl)benzene→Bromido(2-phenylethyl)magnesium→Oxalic acid diethyl diester→2-Oxo-4-phenylbutyric acid ethyl ester→4,5-Ditritium-L-proline→L-Alanine→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine→N-Hydroxysuccinimide→Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline→(2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline
L-Alanine→N-Boc-2(S)-aminopropanoic acid→(4R)-4-Amino-1,3-oxazolidine-2,5-dione→Methyl L-prolinate hydrogen chloride→Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate→N-(tert-Butoxycarbonyl)-L-alanyl-L-proline→L-Proline→L-Alanyl-L-proline→2-Oxo-4-phenylbutyric acid ethyl ester→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
Ethyl 2-oxo-4-phenylbutyrate→L-Alanyl-L-proline
(2-Bromoethyl)benzene→Bromido(2-phenylethyl)magnesium→Oxalic acid diethyl diester→2-Oxo-4-phenylbutyric acid ethyl ester→4,5-Ditritium-L-proline→L-Alanine→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine→N-Hydroxysuccinimide→Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline→(2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline
L-Alanine→N-Boc-2(S)-aminopropanoic acid→(4R)-4-Amino-1,3-oxazolidine-2,5-dione→Methyl L-prolinate hydrogen chloride→Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate→N-(tert-Butoxycarbonyl)-L-alanyl-L-proline→L-Proline→L-Alanyl-L-proline→2-Oxo-4-phenylbutyric acid ethyl ester→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.