CAS 65193-87-5

2-cyanoethyl 3-oxobutanoate2-Cyanoethyl 3-oxobutanoate

Codes: FINE-003, (III)638294-1-a, (II)638294-6-a, (I)638294-17-a, Lercanidipine Hydrochloride-035

Application context (from source-drug indications)

Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneEssential hypertensionValsartan/Lercanidipine HydrochlorideHypertensionLercanidipine Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Finerenone	Tier C — Watch / trade	2030
Valsartan/Lercanidipine Hydrochloride	Tier C — Watch / trade	-
Lercanidipine Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

FinerenoneOriginator routesteps: 7total yield: /

tert-butyl (E)-3-(4-cyano-2-methoxyphenyl)acrylate→4-formyl-3-methoxybenzonitrile→2-cyanoethyl 3-oxobutanoate→2-cyanoethyl (Z)-2-(4-cyano-2-methoxybenzylidene)-3-oxobutanoate→4-amino-5-methylpyridin-2(1H)-one→2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

FinerenoneOptimised routesteps: 7total yield: /

2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide

FinerenoneOptimised routesteps: 7total yield: /

4-Bromo-2-methoxybenzaldehyde→2-Cyanoethyl 3-oxobutanoate→2-Cyanoethyl (2Z)-2-[(4-bromo-2-methoxyphenyl)methylidene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→2-Cyanoethyl 4-(4-bromo-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→2-Cyanoethyl (4S)-4-(4-bromo-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→2-Cyanoethyl (4S)-4-(4-bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4S)-4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→(4S)-4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

FinerenoneOptimised routesteps: 5total yield: /

2-Cyanoethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,6-naphthyridine-3-carboxylate→2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate

Valsartan/Lercanidipine HydrochlorideOptimised routesteps: 9total yield: /

4-Methylene-2-oxetanone→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→(3-Nitrophenyl)methanone→3-Amino-2-butenoic acid methyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(2-cyanoethyl)5-methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol

Valsartan/Lercanidipine HydrochlorideOptimised routesteps: 4total yield: /

Acetoacetic ethyl ester→3-Hydroxypropionitrile→2-Cyanoethyl 3-oxobutanoate→m-Nitrobenzaldehyde→Bis(2-cyanoethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid

Valsartan/Lercanidipine HydrochlorideOptimised routesteps: 5total yield: /

Methyl acetoacetate→3-Hydroxypropionitrile→2-Cyanoethyl 3-oxobutanoate→(E)-2-cyanoethyl 3-aminobut-2-enoate→3-Nitrobenzaldehyde→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(2-Cyanoethyl) 5-Methyl E

Lercanidipine HydrochlorideOptimised routesteps: 9total yield: /

Lercanidipine HydrochlorideOptimised routesteps: 4total yield: /

Lercanidipine HydrochlorideOptimised routesteps: 5total yield: /

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.