CAS 654-70-6

4-amino-2-(trifluoromethyl)benzonitrile

Codes: ENZA-013

Application context (from source-drug indications)

Hormone-sensitive prostate cancerEnzalutamideCastration-resistant prostate cancerEnzalutamideProstate cancerEnzalutamide

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Enzalutamide	Tier A — Act now	2027

Position in synthesis routes (up/downstream chain)

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EnzalutamideOptimised routesteps: 2total yield: 4 mg

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid→4-amino-2-(trifluoromethyl)benzonitrile→4-((1-((4-cyano-3-(trifluoromethyl)phenyl)amino)-2-methyl-1-oxopropan-2-yl)amino)-2-fluoro-N-methylbenzamide

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