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CAS 655-15-2
2-bromo-1-(2-fluorophenyl)ethanone
Codes: VONO-002
Application context (from source-drug indications)
Peptic ulcer bleedingVonoprazan AcetateHelicobacter pylori infectionVonoprazan FumarateOesophagitisVonoprazan FumarateGastro-oesophageal reflux diseaseVonoprazan FumarateHeartburnVonoprazan FumaratePeptic oesophagitisVonoprazan FumarateHelicobacter infectionVonoprazan Fumarate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vonoprazan Acetate | Tier C — Watch / trade | 2029 |
| Vonoprazan Fumarate | Tier C — Watch / trade | - |
| Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→2-(2-fluorobenzoyl)malononitrile→2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→Vonoprazan Fumarate
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride→2-(2-fluorobenzoyl)malononitrile→2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→Vonoprazan Fumarate
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateOriginator routesteps: 10total yield: 912 mg (Vonoprazan Fumarate)
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateOptimised routesteps: 6total yield: 7.57 g (Vonoprazan Fumarate)
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→2-(2-fluorobenzoyl)malononitrile→2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→Vonoprazan Fumarate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | pyridine-3-sulfonyl chloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Vonoprazan Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-Pyridinesulfonyl chloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.