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CAS 65676-21-3
(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile
Codes: Chlorphenamine Maleate-021
Application context (from source-drug indications)
Nasal congestionDextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideSneezingDextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideCoughDextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideCommon coldAcetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/CaffeineHypersensitivity reactionChlorphenamine MaleateSeasonal allergic rhinitisChlorphenamine MaleateDermatitisChlorphenamine MaleateUrticariaChlorphenamine MaleatePruritusChlorphenamine MaleateDrug eruptionChlorphenamine Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chloride | Tier C — Watch / trade | - |
| Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/Caffeine | Tier C — Watch / trade | - |
| Chlorphenamine Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideOptimised routesteps: 5total yield: 64g(Chlorphenamine Maleate (API))
(p-Chlorophenyl)acetonitrile→2-Chloranylpyridine→2-Bromanylpyridine→(4-Chlorophenyl)(pyridin-2-yl)acetonitrile→2-(Dimethylamino)ethyl chloride→1-Chloro-2-dimethylaminoethane hydrochloride→2-(Dimethylamino)ethanol→(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile→1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/CaffeineOptimised routesteps: 5total yield: 64g(Chlorphenamine Maleate (API))
(p-Chlorophenyl)acetonitrile→2-Chloranylpyridine→2-Bromanylpyridine→(4-Chlorophenyl)(pyridin-2-yl)acetonitrile→2-(Dimethylamino)ethyl chloride→1-Chloro-2-dimethylaminoethane hydrochloride→2-(Dimethylamino)ethanol→(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile→1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
(p-Chlorophenyl)acetonitrile→2-Chloranylpyridine→2-Bromanylpyridine→(4-Chlorophenyl)(pyridin-2-yl)acetonitrile→2-(Dimethylamino)ethyl chloride→1-Chloro-2-dimethylaminoethane hydrochloride→2-(Dimethylamino)ethanol→(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile→1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.