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CAS 66-22-8

pyrimidine-2,4(1H,3H)-dione2,4(1H,3H)-Pyrimidinedione2,4-Dihydroxypyrimidine1,2,3,4-Tetrahydropyrimidine-2,4-dione

Codes: DASA-019, Molnupiravir-036, (I)229059-10-a

Application context (from source-drug indications)

Chronic hepatitis CDasabuvir Sodium HydrateHepatitis CDasabuvir Sodium HydrateDecompensated cirrhosisDasabuvir Sodium HydrateRenal impairmentDasabuvir Sodium HydrateFibrosisDasabuvir Sodium HydrateEnd-stage renal diseaseDasabuvir Sodium HydrateCOVID-19Molnupiravir呼吸道合胞体病毒感染MolnupiravirInfluenza virus infectionMolnupiravirRenal impairmentMolnupiravirHepatic function declineMolnupiravir巨细胞病毒感染Vidarabine MonophosphateHerpesvirus infectionVidarabine Monophosphate

Source drugs (routes using this intermediate)

DrugTierExpiry
Dasabuvir Sodium HydrateTier C — Watch / trade-
MolnupiravirTier B — Position early-
Vidarabine MonophosphateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

MolnupiravirOptimised routesteps: 6total yield: 3.5g(Molnupiravir-031)
2,4(1H,3H)-Pyrimidinedione→D-Ribofuranose 1,2,3,5-tetraacetate→Triacetyl uridine→4-Chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)pyrimidin-2(1H)-one→2',3',5'-Tri-O-acetyl-N-hydroxycytidine→N4-Hydroxycytidine
MolnupiravirOptimised routesteps: 3total yield: /
5-O-(2-Methylpropanoyl)-D-ribofuranose→Molnupiravir-012→alpha-Methylpropionic anhydride→2,4-Dihydroxypyrimidine→5'-O-(2-Methylpropanoyl)uridine
MolnupiravirOptimised routesteps: 1total yield: /
Molnupiravir-052→2,4(1H,3H)-Pyrimidinedione→1-(beta-D-Ribofuranosyl)uracil
MolnupiravirOptimised routesteps: 7total yield: 1.65g(Molnupiravir)
1,2,3-Tri-O-acetyl-5-O-(triphenylmethyl)-D-ribofuranose→2',3'-Di-O-acetyluridine→2',3'-Di-O-acetyl-5'-O-(2-methylpropanoyl)uridine→1-[2,3-Di-O-acetyl-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-[[2,4,6-tri(propan-2-yl)benzene-1-sulfonyl]oxy]pyrimidin-2(1H)-one→Molnupiravir-052→2,4(1H,3H)-Pyrimidinedione→2-Methylpropionic anhydride→Hydroxylamine hydrochloride
MolnupiravirOptimised routesteps: 10total yield: /
2(S)-(1,1,1-Triphenylmethoxymethyl)oxirane→(Vinyl)magnesium bromide→(2S)-1-(Triphenylmethoxy)pent-4-en-2-ol→(3S)-3-[[tert-Butyl(diphenyl)silyl]oxy]-4-(triphenylmethoxy)butanal→(2S,3aS,9aR)-2-[(Triphenylmethoxy)methyl]-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-6-one→Iodoform→tert-Butyl[[(2S,4E)-5-iodo-1-(triphenylmethoxy)pent-4-en-2-yl]oxy]diphenylsilane→1-[(1E,4S)-4-Hydroxy-5-(triphenylmethoxy)pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione→1-[(2R,5S)-5-(Trityloxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione→[(2S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl 2-methylpropanoate→2,4(1H,3H)-Pyrimidinedione→2-Methylpropionic anhydride→5'-O-(2-Methylpropanoyl)uridine→Hydroxylamine sulfate
Vidarabine MonophosphateOptimised routesteps: 1total yield: /
1,2,3,4-Tetrahydropyrimidine-2,4-dione→[(2R,3S,4S,5R)-3,4,5,6-Tetrahydroxyoxan-2-yl]methyl phosphate→1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Taizhou GMP-like Site((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate
Pharmaceutical Intermediates
On requestOn requestOn request
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.