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CAS 666816-98-4
8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
Codes: LINA-003
Application context (from source-drug indications)
Type 2 diabetesLinagliptin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Linagliptin | Tier C — Watch / trade | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione→1-bromobut-2-yne→8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→(R)-tert-butyl piperidin-3-ylcarbamate→tert-butyl (R)-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione→1-bromobut-2-yne→8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→(R)-piperidin-3-amine dihydrochloride
8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→1-(2-aminophenyl)ethan-1-one→2-chloroacetonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione (2S,3S)-2,3-dihydroxysuccinate→(R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→pyridin-3-amine→piperidin-3-amine→isobenzofuran-1,3-dione→2-(piperidin-3-yl)isoindoline-1,3-dione→(2S,3S)-2,3-dihydroxysuccinic acid
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | On request | On request | On request | — |
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