CAS 67-56-1

Hydroxymethane

Codes: (XXXVI)638294-1-d, Ioflupane (123I)-008, (XXVI)145089-2-c

Application context (from source-drug indications)

Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneLewy body dementiaIoflupane (123I)Diagnostic agentIoflupane (123I)ParkinsonismIoflupane (123I)Alzheimer's diseaseIoflupane (123I)Parkinson's diseaseIoflupane (123I)DementiaIoflupane (123I)Alzheimer's diseaseRivastigmine TartrateDementiaRivastigmine TartrateParkinson's diseaseRivastigmine Tartrate抗胆碱能综合征Rivastigmine Tartrate神经行为学表现Rivastigmine TartrateCognitive impairmentRivastigmine Tartrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Finerenone	Tier C — Watch / trade	2030
Ioflupane (123I)	Tier C — Watch / trade	-
Rivastigmine Tartrate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

FinerenoneOptimised routesteps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

Ioflupane (123I)Optimised routesteps: 8total yield: /

8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate

Rivastigmine TartrateOptimised routesteps: 4total yield: /

1(S)-(3-Methoxyphenyl)-N,N-dimethylethylamine→(+/-)-3-Methoxy-alpha-methylbenzyl alcohol→(S)-(-)-2-Methyl-2-propanesulfinamide→(SS)-N-[(1S)-1-(3-Methoxyphenyl)ethyl]-2-methylpropane-2-sulfinamide→(1S)-1-(3-Methoxyphenyl)ethanamine→1-Ethyl-3-iodobenzene→Benzamide→N-[(1S)-1-(3-Iodophenyl)ethyl]benzamide→Hydroxymethane→N-[(1S)-1-(3-Methoxyphenyl)ethyl]benzamide→1,1,1-Triphenylmethanamine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	On request	On request	On request	—

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