CAS 673487-36-0

4-chloro-3-methylbenzene-1,2-diamine

Codes: NEMOR-003

Application context (from source-drug indications)

Insomnia and sleep disordersDaridorexant hydrochlorideAlcohol abuseDaridorexant hydrochlorideAlzheimer's diseaseDaridorexant hydrochloride术后认知障碍并发症Daridorexant hydrochloride谵妄Daridorexant hydrochlorideObstructive sleep apnoea syndromeDaridorexant hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Daridorexant hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Daridorexant hydrochlorideOriginator routesteps: 6total yield: /

(S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride→(S)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid→4-chloro-3-methylbenzene-1,2-diamine→tert-butyl (S)-2-((2-amino-4-chloro-3-methylphenyl)carbamoyl)-2-methylpyrrolidine-1-carboxylate→tert-butyl (S)-2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidine-1-carboxylate→(S)-5-chloro-4-methyl-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole hydrochloride→5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid→2-iodo-5-methoxybenzoic acid→2H-1,2,3-triazole→(S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	6-Chloro-2,3-diaminotoluene Pharmaceutical Intermediates	On request	On request	On request	—

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