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CAS 674-82-8
4-methyleneoxetan-2-one3-Hydroxy 3-butenoic acid beta-lactone4-Methylene-2-oxetanone4-Methyleneoxetan-2-one
Codes: PALB-037, (II)638294-21-a, Atorvastatin-136, (I)180072-57-a, Lercanidipine Hydrochloride-001, SUNT-001, Cefcamate Pivoxil Hydrochloride-030
Application context (from source-drug indications)
Breast cancerPalbociclibSystolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneCardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateEssential hypertensionValsartan/Lercanidipine HydrochlorideHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontiumPancreatic neuroendocrine tumourSunitinib MalateRenal cell carcinomaSunitinib MalateGastrointestinal stromal tumourSunitinib MalateOsteosarcomaSunitinib MalateSarcomaSunitinib MalateLymphomaSunitinib MalateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotateHypertensionLercanidipine HydrochlorideHypertensionAmlodipine CamsylateBacterial infectionCefcamate Pivoxil Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Palbociclib | Tier A — Act now | 2027 |
| Finerenone | Tier C — Watch / trade | 2030 |
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Olmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
| Sunitinib Malate | Tier B — Position early | - |
| Amlodipine Orotate | Tier C — Watch / trade | - |
| Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Amlodipine Camsylate | Tier C — Watch / trade | - |
| Cefcamate Pivoxil Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→2,4-dichloropyrimidine-5-carbonitrile→1-(2,4-dichloropyrimidin-5-yl)ethanone→2,4-dichloro-5-(2-methyl-1,3-dioxolan-2-yl)pyrimidine→1-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)ethanone→4-methyleneoxetan-2-one→N-(5-acetyl-2-chloropyrimidin-4-yl)-N-cyclopentyl-3-oxobutanamide→6-acetyl-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→2-chloro-8-cyclopentyl-5-methyl-6-(2-methyl-1,3-dioxolan-2-yl)pyrido[2,3-d]pyrimidin-7(8H)-one→tert-butyl 4-(6-((8-cyclopentyl-5-methyl-6-(2-methyl-1,3-dioxolan-2-yl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
(R)-4-(Phenylmethyl)-2-oxazolidinone→3-Hydroxy 3-butenoic acid beta-lactone→1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidin-3-yl]butane-1,3-dione→2-Methoxy-4-cyanobenzaldehyde→4-[2-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-3-oxobut-1-en-1-yl]-3-methoxybenzonitrile→4-Amino-5-methylpyridin-2(1H)-one→4-[3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile→4-[(4S)-3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile→1,1,1-Triethoxyethane→4-[(4S)-3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 11total yield: 25g(Atorvastatin-017)
1,4-Epoxy-1,3-butadiene→(2E)-1,1,4,4-Tetramethoxybut-2-ene→2,2-Dimethoxyacetaldehyde→Nitrocarbol→tert-Butyl 4-bromo-3-oxobutanoate→1,1-Dimethoxy-3-nitropropan-2-ol→(1E)-3,3-Dimethoxy-1-nitroprop-1-ene→(2E)-3-Nitroprop-2-enal→Bromido(4-tert-butoxy-2,4-dioxobutyl)zinc→tert-Butyl (5S,6E)-5-hydroxy-7-nitro-3-oxohept-6-enoate→4-Methylene-2-oxetanone→tert-Butyl (3R,5S,6E)-3,5-dihydroxy-7-nitrohept-6-enoate→2-Propanone→tert-Butyl [(4R,6S)-2,2-dimethyl-6-[(E)-2-nitroethenyl]-1,3-dioxan-4-yl]acetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester
4-Methyleneoxetan-2-one→4-Chloro-3-oxobutanoic acid
4-Methyleneoxetan-2-one→4-Chloro-3-oxobutanoic acid
4-Methylene-2-oxetanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
4-Methylene-2-oxetanone→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→(3-Nitrophenyl)methanone→3-Amino-2-butenoic acid methyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(2-cyanoethyl)5-methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol
1,4-Epoxy-1,3-butadiene→(2E)-1,1,4,4-Tetramethoxybut-2-ene→2,2-Dimethoxyacetaldehyde→Nitrocarbol→tert-Butyl 4-bromo-3-oxobutanoate→1,1-Dimethoxy-3-nitropropan-2-ol→(1E)-3,3-Dimethoxy-1-nitroprop-1-ene→(2E)-3-Nitroprop-2-enal→Bromido(4-tert-butoxy-2,4-dioxobutyl)zinc→tert-Butyl (5S,6E)-5-hydroxy-7-nitro-3-oxohept-6-enoate→4-Methylene-2-oxetanone→tert-Butyl (3R,5S,6E)-3,5-dihydroxy-7-nitrohept-6-enoate→2-Propanone→tert-Butyl [(4R,6S)-2,2-dimethyl-6-[(E)-2-nitroethenyl]-1,3-dioxan-4-yl]acetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester
4-methyleneoxetan-2-one→N1,N1-diethylethane-1,2-diamine→N-(2-(diethylamino)ethyl)-3-oxobutanamide→tert-butyl 3-oxobutanoate→tert-butyl 4-((2-(diethylamino)ethyl)carbamoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate→N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide→N-(chloromethylene)-N-methylmethanaminium chloride→N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide→5-fluoroindolin-2-one→(S)-2-hydroxysuccinic acid
4-Methyleneoxetan-2-one→4-Chloro-3-oxobutanoic acid
4-Methylene-2-oxetanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
4-Methylene-2-oxetanone→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→(3-Nitrophenyl)methanone→3-Amino-2-butenoic acid methyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(2-cyanoethyl)5-methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol
4-Methyleneoxetan-2-one→4-Chloro-3-oxobutanoic acid
Cefcamate Pivoxil HydrochlorideOptimised routesteps: 3total yield: 48.6g(Cefcamate Pivoxil Hydrochloride-004)
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | PD 0332991 HCl Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-Fluoro-2-oxindole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.