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CAS 676129-92-3
(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
Codes: VALS-011
Application context (from source-drug indications)
HypertensionLevamlodipine Besylate/ValsartanEssential hypertensionLevamlodipine Besylate/ValsartanEssential hypertensionValsartan/Amlodipine OrotateEssential hypertensionValsartan/Lercanidipine HydrochlorideLeft ventricular dysfunctionValsartanHypertensionValsartanEssential hypertensionValsartanPulmonary arterial hypertensionValsartanRight ventricular dysfunctionValsartanPost-myocardial infarction syndromeValsartan
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Levamlodipine Besylate/Valsartan | Tier C — Watch / trade | - |
| Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Valsartan | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
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