CAS 70500-72-0

7-hydroxyquinolin-2(1H)-one7-Hydroxycarbostyril

Codes: BREX-001

Physicochemical properties & identification

Appearance: White to off-white powder
Solubility: Slightly soluble in water; soluble in hot DMF, DMSO and aqueous alkali
Storage: Ambient temperature, dry, protected from light

Applications

· Key quinolinone-core intermediate for brexpiprazole (a D2 / 5-HT1A partial agonist)
· A general substrate for methodology studies on quinolone-type heterocycles

Application context (from source-drug indications)

SchizophreniaBrexpiprazoleAlzheimer's diseaseBrexpiprazoleAgitationBrexpiprazoleDepressionBrexpiprazoleDepressive disorderBrexpiprazoleMajor depressive disorderBrexpiprazole

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Brexpiprazole	Tier A — Act now	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

BrexpiprazoleOriginator routesteps: 3total yield: 13.6 g

7-hydroxyquinolin-2(1H)-one→1-bromo-4-chlorobutane→7-(4-chlorobutoxy)quinolin-2(1H)-one→1-(benzo[b]thiophen-4-yl)piperazine hydrochloride→4-bromobenzo[b]thiophene→piperazine

BrexpiprazoleProcess routesteps: 7total yield: 14.3 g

2-chloro-6-fluorobenzaldehyde→2-thioxothiazolidin-4-one→(Z)-5-(2,6-dichlorobenzylidene)-2-thioxothiazolidin-4-one→(Z)-3-(2,6-dichlorophenyl)-2-mercaptoacrylic acid→4-chlorobenzo[b]thiophene-2-carboxylic acid→4-chlorobenzo[b]thiophene→7-hydroxyquinolin-2(1H)-one→1-bromo-4-chlorobutane→7-(4-chlorobutoxy)quinolin-2(1H)-one→1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	7-Hydroxyquinolinone Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.