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CAS 707-07-3
(Trimethoxymethyl)benzene(trimethoxymethyl)benzene
Codes: (III)101438-32-a, NINT-006
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateSystemic sclerosis-associated interstitial lung diseaseNintedanib EsylateIdiopathic pulmonary fibrosisNintedanib EsylateNon-small cell lung cancerNintedanib EsylatePulmonary fibrosisNintedanib EsylateInterstitial lung diseaseNintedanib EsylateHereditary haemorrhagic telangiectasiaNintedanib EsylatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxel
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Nintedanib Esylate | Tier B — Position early | - |
| Paclitaxel | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-Phenyl-2-propenoic acid methyl ester→Methyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate→(Trimethoxymethyl)benzene→(1S,2R)-1-Hydroxy-3-methoxy-3-oxo-1-phenylpropan-2-yl benzoate→(1R,2S)-1-Bromo-3-methoxy-3-oxo-1-phenylpropan-2-yl benzoate→(1S,2R)-1-Azido-3-methoxy-3-oxo-1-phenylpropan-2-yl benzoate→Methyl (2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoate→Methyl 3-benzamido-2-oxo-3-phenylpropanoate
methyl 3-nitrobenzoate→methyl 2-chloroacetate→methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate→methyl 2-oxo-1,3-dihydroindole-6-carboxylate →methyl 1-acetyl-2-oxoindoline-6-carboxylate→(trimethoxymethyl)benzene→(Z)-methyl 1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→2-bromo-N-methyl-N-(4-nitrophenyl)acetamide→1-methylpiperazine→N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
methyl 2-oxo-1,3-dihydroindole-6-carboxylate →(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→1-methylpiperazine→4-chloro-3-nitrobenzoic acid→methyl 4-chloro-3-nitrobenzoate→dimethyl malonate→dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate→2-chloroacetic anhydride→methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate→(Z)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→(Z)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→ethanesulfonic acid→N-methyl-4-nitroaniline→2-chloroacetyl chloride→2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate→(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→(Z)-methyl 4-(1,3-dimethoxy-3-oxo-1-phenylprop-1-en-2-yl)-3-nitrobenzoate→(Z)-methyl 4-(3-methoxy-1-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)-3-oxo-1-phenylprop-1-en-2-yl)-3-nitrobenzoate
3-Phenyl-2-propenoic acid methyl ester→Methyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate→(Trimethoxymethyl)benzene→(1S,2R)-1-Hydroxy-3-methoxy-3-oxo-1-phenylpropan-2-yl benzoate→(1R,2S)-1-Bromo-3-methoxy-3-oxo-1-phenylpropan-2-yl benzoate→(1S,2R)-1-Azido-3-methoxy-3-oxo-1-phenylpropan-2-yl benzoate→Methyl (2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoate→Methyl 3-benzamido-2-oxo-3-phenylpropanoate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | On request | On request | On request | — |
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