CAS 714273-83-3

5-(tert-butyl)-1H-imidazole-4-carbaldehyde

Codes: PLIN-004

Application context (from source-drug indications)

Non-small cell lung cancerPlinabulinNeutropeniaPlinabulinMultiple myelomaPlinabulinLung cancerPlinabulinSmall cell lung cancerPlinabulinMerkel细胞癌Plinabulin

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Plinabulin	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

PlinabulinOriginator routesteps: 2total yield: 0.80 mg (Plinabulin)

1,4-diacetylpiperazine-2,5-dione→benzaldehyde→(Z)-1-acetyl-3-benzylidenepiperazine-2,5-dione→5-(tert-butyl)-1H-imidazole-4-carbaldehyde

PlinabulinOptimised routesteps: 6total yield: 1.59 g (Plinabulin)

1,4-diacetylpiperazine-2,5-dione→benzaldehyde→5-(tert-butyl)-1H-imidazole-4-carbaldehyde→ethyl 4,4-dimethyl-3-oxopentanoate→ethyl 2-chloro-4,4-dimethyl-3-oxopentanoate→formamide→ethyl 5-(tert-butyl)-1H-imidazole-4-carboxylate→(5-(tert-butyl)-1H-imidazol-4-yl)methanol→(Z)-1-acetyl-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

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