← Back to patent-cliff list
CAS 72155-45-4
(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate
Codes: ATAZ-025, RITO-038
Application context (from source-drug indications)
HIV infectionAtazanavir Sulfate/CobicistatChronic hepatitis CParitaprevir/Ombitasvir/RitonavirHepatitis CParitaprevir/Ombitasvir/RitonavirDecompensated cirrhosisParitaprevir/Ombitasvir/RitonavirRenal impairmentParitaprevir/Ombitasvir/RitonavirFibrosisParitaprevir/Ombitasvir/RitonavirEnd-stage renal diseaseParitaprevir/Ombitasvir/RitonavirHIV infectionDarunavir Ethanolate/RitonavirHIV infectionRitonavirKaposi's sarcomaRitonavirBreast cancerRitonavirHIV infectionAtazanavir SulfateAcquired immunodeficiency syndromeAtazanavir SulfateMycobacterium tuberculosis infectionAtazanavir SulfateType 1 diabetesAtazanavir Sulfate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atazanavir Sulfate/Cobicistat | Tier C — Watch / trade | - |
| Paritaprevir/Ombitasvir/Ritonavir | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| Ritonavir | Tier C — Watch / trade | - |
| Atazanavir Sulfate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl hydrazinecarboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→methyl 4-cyanobenzoate→methyl 4-(pyridin-2-yl)benzoate→4-(pyridin-2-yl)benzoic acid→(isobutyl carbonic) 4-(pyridin-2-yl)benzoic anhydride→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(1R,2S)-2-((tert-butoxycarbonyl)amino)-1-cyano-3-phenylpropyl 4-(pyridin-2-yl)benzoate→tert-butyl (E)-2-((2R,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butylidene)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butyl)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzoyl)hydrazine-1-carboxylate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
tert-butyl hydrazinecarboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→methyl 4-cyanobenzoate→methyl 4-(pyridin-2-yl)benzoate→4-(pyridin-2-yl)benzoic acid→(isobutyl carbonic) 4-(pyridin-2-yl)benzoic anhydride→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(1R,2S)-2-((tert-butoxycarbonyl)amino)-1-cyano-3-phenylpropyl 4-(pyridin-2-yl)benzoate→tert-butyl (E)-2-((2R,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butylidene)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butyl)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzoyl)hydrazine-1-carboxylate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.