CAS 72830-07-0

3,4-Dimethoxy-2-methylpyridine 1-oxide

Codes: S-pantoprazole sodium-025, S-pantoprazole sodium-019

Application context (from source-drug indications)

Gastro-oesophageal reflux diseaseS-pantoprazole sodiumPeptic ulcerS-pantoprazole sodiumHaemorrhageS-pantoprazole sodiumTrauma and injuryS-pantoprazole sodiumComaS-pantoprazole sodiumAspiration pneumoniaS-pantoprazole sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
S-pantoprazole sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

S-pantoprazole sodiumOptimised routesteps: 10total yield: /

(3,4-Dimethoxypyridin-2-yl)methanol→2-Methylpyridin-3-ol→3-methoxy-2-methylpyridine→3-methoxy-2-methyl-1-oxidopyridin-1-ium→3-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium→3,4-Dimethoxy-2-methylpyridine 1-oxide→Acetic anhydride→(3,4-dimethoxypyridin-2-yl)methyl acetate→3-methoxypyridine→4-Chloro-3-methoxypyridine hydrochloride→2-Oxopropionic acid ethyl ester→ethyl 4-chloro-3-methoxypyridine-2-carboxylate→methyl 3,4-dimethoxypyridine-2-carboxylate

S-pantoprazole sodiumOptimised routesteps: 11total yield: 5.2g((S)-(-)-Pantoprazole sodium (API))

3-Hydroxy-2-methyl-4H-pyran-4-one→3-Methoxy-2-methyl-4H-pyran-4-one→3-Methoxy-2-methylpyridin-4-one→4-Chloro-3-methoxy-2-methylpyridine→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→4-Chloro-3-methoxy-2-methylpyridine 1-oxide→3,4-Dimethoxy-2-methylpyridine 1-oxide→(3,4-Dimethoxypyridin-2-yl)methanol→2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole

S-pantoprazole sodiumOptimised routesteps: 3total yield: 25g(S-pantoprazole sodium-025)

3-Hydroxy-2-methyl-4H-pyran-4-one→3,4-Dimethoxy-2-methylpyridine 1-oxide→3-Hydroxy-2-methylpyridin-4(1H)-one→3,4-Dimethoxy-2-methylpyridine

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