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CAS 731851-41-5
3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
Codes: IRBE-015
Application context (from source-drug indications)
HypertensionAtorvastatin Calcium Hydrate/IrbesartanHyperlipidaemiaAtorvastatin Calcium Hydrate/IrbesartanHypertensionIrbesartan/TrichlormethiazideOesophageal diseaseIrbesartanHypertensionIrbesartanDiabetic nephropathyIrbesartanHypercholesterolaemiaIrbesartanAlbuminuriaIrbesartanType 2 diabetesIrbesartan
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin Calcium Hydrate/Irbesartan | Tier C — Watch / trade | - |
| Irbesartan/Trichlormethiazide | Tier C — Watch / trade | - |
| Irbesartan | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,4-dibromobenzene→4-bromobenzaldehyde→(4-bromophenyl)methanol→1-bromo-4-(bromomethyl)benzene→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride→3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid
1,4-dibromobenzene→4-bromobenzaldehyde→(4-bromophenyl)methanol→1-bromo-4-(bromomethyl)benzene→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride→3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid
1,4-dibromobenzene→4-bromobenzaldehyde→(4-bromophenyl)methanol→1-bromo-4-(bromomethyl)benzene→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride→3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid
Intermediates available on this site
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