CAS 74-11-3

4-Carboxychlorobenzenep-Chlorobenzoic acid4-chlorobenzoic acid

Codes: (II)461018-33-a, Tetracaine-013, VISM-009, DABI-028

Application context (from source-drug indications)

Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibAnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideBasal cell carcinomaVismodegibMultiple myelomaVismodegibLymphomaVismodegibSolid tumourVismodegibHaematological malignancyVismodegibMesenchymal chondrosarcomaVismodegibVenous thromboembolismDabigatran Etexilate MesylateEmbolismDabigatran Etexilate MesylateStrokeDabigatran Etexilate MesylateIschaemic strokeDabigatran Etexilate MesylatePulmonary embolismDabigatran Etexilate MesylateVenous thrombosisDabigatran Etexilate MesylateAnaesthesiaTetracaine HydrochlorideRetinitis pigmentosaTetracaine HydrochloridePainTetracaine Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ibrutinib	Tier A — Act now	2027
Oxymetazoline Hydrochloride/Tetracaine Hydrochloride	Tier C — Watch / trade	-
Vismodegib	Tier C — Watch / trade	-
Dabigatran Etexilate Mesylate	Tier B — Position early	-
Tetracaine Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

IbrutinibOptimised routesteps: 2total yield: /

Carbolic acid→4-Carboxychlorobenzene→4-(Phenyloxy)benzoic acid→Phenol sodium salt

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 10total yield: /

4-Aminobenzoic acid sodium salt→4-(Butylamino)benzoic acid→p-Chlorobenzoic acid→4-Bromobenzoic acid→4-Iodobenzoic acid→Butylamine→4-(Butylamino)benzoic acid ethyl ester→2-(Dimethylamino)ethanol hydrochloride→2-Chloroethanol→4-(Butylamino)benzoic acid 2-chloroethyl ester→N-Methylmethanamine→n-Butyl bromide→N,N-Dimethylaminoethanol→4-Aminobenzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

VismodegibOptimised routesteps: 6total yield: 165.3 g

2-chloro-4-(methylsulfonyl)benzoyl chloride→4-chlorobenzoic acid→4-chloro-3-iodobenzoic acid→tert-butyl (4-chloro-3-iodophenyl)carbamate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→tert-butyl (4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate→2-bromopyridine→tert-butyl (4-chloro-3-(pyridin-2-yl)phenyl)carbamate→4-chloro-3-(pyridin-2-yl)aniline

Dabigatran Etexilate MesylateOptimised routesteps: 9total yield: 44 g

4-(methylamino)-3-nitrobenzoic acid→4-(methylamino)-3-nitrobenzoyl chloride→ethyl 3-(pyridin-2-ylamino)propanoate→ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate→ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate→2-((4-cyanophenyl)amino)acetic acid→ethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate→hexyl carbonochloridate→4-chloro-3-nitrobenzoic acid→4-chlorobenzoic acid→ethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate→ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate oxalate

Tetracaine HydrochlorideOptimised routesteps: 10total yield: /

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	Dabigatran etexilate mesylate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta-alaninate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	N-(4-cyanophenyl)-Glycine Pharmaceutical Intermediates	On request	On request	On request	—

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