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CAS 7432-21-5
(S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid
Codes: MACIM-001, EPTI-027
Application context (from source-drug indications)
Growth hormone deficiencyMacimorelin AcetateCachexiaMacimorelin AcetateUnstable anginaEptifibatideMyocardial infarctionEptifibatideIschaemic strokeEptifibatideAcute coronary syndromeEptifibatideSickle cell diseaseEptifibatideST段抬高型心肌梗死Eptifibatide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Macimorelin Acetate | Tier C — Watch / trade | - |
| Eptifibatide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid→(S)-benzyl (1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate→(S)-2-amino-3-(1H-indol-3-yl)propanamide→tert-butyl ((R)-1-(((R)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate→tert-butyl 3-((R)-3-amino-2-((R)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-2-((tert-butoxycarbonyl)amino)propanamido)-3-oxopropyl)-1H-indole-1-carboxylate→tert-butyl 3-((R)-2-amino-2-((R)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-2-((tert-butoxycarbonyl)amino)propanamido)ethyl)-1H-indole-1-carboxylate
2-aminoacetic acid→methyl glycinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-6-guanidinohexanoic acid→(S)-methyl 2-(2-amino-6-guanidinohexanamido)acetate→3-((acetamidomethyl)thio)propanoic acid→(S)-10-(4-guanidinobutyl)-2,8,11-trioxo-5-thia-3,9,12-triazatetradecan-14-oic acid→(S)-methyl 1-((S)-2-((S)-2-amino-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(S)-1-((10S,16S,19S)-19-((1H-indol-3-yl)methyl)-16-(2-(tert-butoxy)-2-oxoethyl)-10-(4-guanidinobutyl)-2,8,11,14,17-pentaoxo-5-thia-3,9,12,15,18-pentaazaicosan-20-oyl)pyrrolidine-2-carboxylic acid→(R)-3-((acetamidomethyl)thio)-2-aminopropanamide→(S)-pyrrolidine-2-carboxylic acid→methyl L-prolinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid→(S)-methyl 1-((S)-2-amino-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(S)-2-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid
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