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CAS 75-16-1
Methylmagnesium bromideBromo(methyl)magnesium
Codes: (IX)101438-68-a, (XV)101438-70-b, (III)700647-1-a, (XV)909096-1-b
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxel蠕形螨性睑缘炎Lotilaner螨虫感染Lotilaner莱姆病LotilanerRosaceaLotilaner睑板腺功能障碍LotilanerNon-small cell lung cancerIruplinalkib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Lotilaner | Tier C — Watch / trade | - |
| Iruplinalkib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3S,4aR,6R,11S,12aS)-3-Bromo-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(3S,4aR,6R,12aR)-3-Bromo-9,12a,13,13-tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,11S,12aS)-9,12a,13,13-Tetramethyl-11-[(triethylsilyl)oxy]-4a,6,7,11,12,12a-hexahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→1,1-Dibromo-2,2,3,3-tetramethylcyclopropane→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5(1H,4aH)-dione→(Vinyl)magnesium bromide→1,1,2,2-Tetramethylethylene→2-Hydroxy-2-methylbutanoic acid→2-Propen-1-one→3-(3-Isopropenyl-4-methyl-3-pentenyl)-2-cyclohexen-1-one→3-Bromo-2,4-dimethylpenta-1,3-diene→3-Ethenylcyclohex-2-en-1-one→3-Ethoxy-2-cyclohexen-1-one→Aluminum trimethanide→Methylmagnesium bromide→Bromoform→Trimethyl([(3S)-3-methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]oxy)silane→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2S,3S)-2,3-Dimethyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one→(2S,3S)-3-Methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one
(aS)-(-)-1,1'-Bi-2-naphthol→(aS)-[1,1'-Binaphthalene]-2,2'-diyl bis(trifluoromethanesulfonate)→Methylmagnesium bromide→(aS)-2,2'-Dimethyl-1,1'-binaphthalene→(aS)-4-tert-Butyl-4,5-dihydro-3H-4lambda5-dinaphtho[2,1-c:1',2'-e]phosphepine-4-thione→(aS)-(4R,4'R)-4,4'-Di-tert-butyl-4,4',5,5'-tetrahydro-3H,3'H-[3,3'-bi-4lambda5-dinaphtho[2,1-c:1',2'-e]phosphepine]-4,4'-dithione
(3S,4aR,6R,11S,12aS)-3-Bromo-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(3S,4aR,6R,12aR)-3-Bromo-9,12a,13,13-tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,11S,12aS)-9,12a,13,13-Tetramethyl-11-[(triethylsilyl)oxy]-4a,6,7,11,12,12a-hexahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→1,1-Dibromo-2,2,3,3-tetramethylcyclopropane→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5(1H,4aH)-dione→(Vinyl)magnesium bromide→1,1,2,2-Tetramethylethylene→2-Hydroxy-2-methylbutanoic acid→2-Propen-1-one→3-(3-Isopropenyl-4-methyl-3-pentenyl)-2-cyclohexen-1-one→3-Bromo-2,4-dimethylpenta-1,3-diene→3-Ethenylcyclohex-2-en-1-one→3-Ethoxy-2-cyclohexen-1-one→Aluminum trimethanide→Methylmagnesium bromide→Bromoform→Trimethyl([(3S)-3-methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]oxy)silane→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2S,3S)-2,3-Dimethyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one→(2S,3S)-3-Methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one
(aS)-(-)-1,1'-Bi-2-naphthol→(aS)-[1,1'-Binaphthalene]-2,2'-diyl bis(trifluoromethanesulfonate)→Methylmagnesium bromide→(aS)-2,2'-Dimethyl-1,1'-binaphthalene→(aS)-4-tert-Butyl-4,5-dihydro-3H-4lambda5-dinaphtho[2,1-c:1',2'-e]phosphepine-4-thione→(aS)-(4R,4'R)-4,4'-Di-tert-butyl-4,4',5,5'-tetrahydro-3H,3'H-[3,3'-bi-4lambda5-dinaphtho[2,1-c:1',2'-e]phosphepine]-4,4'-dithione
4-Methylthiophene-2-carboxylic acid→N-Methoxy-N,4-dimethylthiophene-2-carboxamide→Bromo(methyl)magnesium→1-(4-Methylthiophen-2-yl)ethan-1-one→3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazole→1-(5-Bromo-4-methylthiophen-2-yl)ethan-1-one→2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethan-1-one→1-(5-Bromo-4-methylthiophen-2-yl)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-en-1-one→Amino alcohol hydrochloride→3-Methyl-5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→3-Methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→5-Bromo-1,2,3-trichlorobenzene→(3,4,5-Trichlorophenyl)magnesium bromide→2,2,2-Trifluoro-N,N-dimethylacetamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.