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CAS 75-21-8
oxirane
Codes: PRUC-004, FLUR-002
Application context (from source-drug indications)
ConstipationPrucalopride SuccinatePostoperative complicationPrucalopride SuccinateEnteral feeding intolerancePrucalopride SuccinateOpioid-induced constipationPrucalopride SuccinatePainPrucalopride SuccinateIntestinal pseudo-obstructionPrucalopride SuccinateCoronary artery diseaseFlurpiridaz F-18Ischaemic heart diseaseFlurpiridaz F-18Diagnostic agentFlurpiridaz F-18Coronary artery lesionFlurpiridaz F-18Non-small cell lung cancerFlurpiridaz F-18心脏毒性作用Flurpiridaz F-18
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Prucalopride Succinate | Tier C — Watch / trade | - |
| Flurpiridaz F-18 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-methoxyaniline→pivaloyl chloride→N-(3-methoxyphenyl)pivalamide→oxirane→N-(2-(2-hydroxyethyl)-3-methoxyphenyl)pivalamide→2,3-dihydrobenzofuran-4-amine→5-chloro-2,3-dihydrobenzofuran-4-amine→7-bromo-5-chloro-2,3-dihydrobenzofuran-4-amine→4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid→1-(3-methoxypropyl)piperidin-4-amine
methyl 4-(hydroxymethyl)benzoate→oxirane→methyl 4-((2-hydroxyethoxy)methyl)benzoate→methyl 4-((2-((tert-butyldimethylsilyl)oxy)ethoxy)methyl)benzoate→(4-((2-((tert-butyldimethylsilyl)oxy)ethoxy)methyl)phenyl)methanol→2-(tert-butyl)-4-chloro-5-hydroxypyridazin-3(2H)-one→2-(tert-butyl)-5-((4-((2-((tert-butyldimethylsilyl)oxy)ethoxy)methyl)benzyl)oxy)-4-chloropyridazin-3(2H)-one→2-(tert-butyl)-4-chloro-5-((4-((2-hydroxyethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one→2-((4-(((1-(tert-butyl)-5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)oxy)methyl)benzyl)oxy)ethyl 4-methylbenzenesulfonate
Intermediates available on this site
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