CAS 75-31-0

propan-2-amineN-IsopropylaminePropan-2-amineMonoisopropylamine

Codes: ABEM-001, Bisoprolol-004, BELOH-002

Application context (from source-drug indications)

Breast cancerAbemaciclibHypertensionAmlodipine Besylate/Bisoprolol FumarateEssential hypertensionAmlodipine Besylate/Bisoprolol FumarateHypertensionBisoprolol FumarateAngina pectorisBisoprolol FumarateChronic obstructive pulmonary diseaseBisoprolol FumarateCardiac and vascular disordersBisoprolol FumarateAcute coronary syndromeBisoprolol FumarateFastingBisoprolol FumarateNon-small cell lung cancerBelotecan HydrochlorideOvarian cancerBelotecan HydrochlorideSolid tumourBelotecan Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Abemaciclib	Tier A — Act now	2029
Amlodipine Besylate/Bisoprolol Fumarate	Tier C — Watch / trade	-
Bisoprolol Fumarate	Tier C — Watch / trade	-
Belotecan Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

AbemaciclibOriginator routesteps: 9total yield: 20.4 g

propan-2-amine→N-isopropylacetamide→4-bromo-2,6-difluoroaniline→(E)-N'-(4-bromo-2,6-difluorophenyl)-N-isopropylacetimidamide→6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole→2,4-dichloro-5-fluoropyrimidine→6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine→1-ethylpiperazine→6-bromonicotinaldehyde→1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 6total yield: /

Phenol→2-(Chloromethyl)oxirane→2-(phenoxymethyl)oxirane→N-Isopropylamine→Ethylene glycol monoisopropyl ether→(2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine→Diethyl carbonate→5-(phenoxymethyl)-3-(propan-2-yl)-1,3-oxazolidin-2-one→5-[4-(chloromethyl)phenoxymethyl]-3-(propan-2-yl)-1,3-oxazolidin-2-one→3-(propan-2-yl)-5-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)-1,3-oxazolidin-2-one

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 3total yield: /

4-Hydroxybenzyl alcohol→4-[(2-Isopropoxyethoxy)methyl]phenol→2-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)oxirane→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol→(+/-)-2-(Chloromethyl)oxirane→Propan-2-amine→Isopropylglycol

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 4total yield: /

4-Hydroxybenzaldehyde→4-(Hydroxymethyl)phenol→Ethylene glycol monoisopropyl ether→4-[(2-Isopropoxyethoxy)methyl]phenol→Epichlorohydrin→2-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxymethyl)oxirane→Propan-2-amine

Amlodipine Besylate/Bisoprolol FumarateOptimised routesteps: 4total yield: 5.57g(Bisoprolol-030)

4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenyl methanesulfonate→(R)-Glycidol→(2S)-2-[[4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenoxy]methyl]oxirane→(-)-1-[4-(2-Isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2(S)-propanol→But-2-enedioic acid (2S)-1-[(propan-2-yl)amino]-3-[4-([2-[(propan-2-yl)oxy]ethoxy]methyl)phenoxy]propan-2-ol→4-[(2-Isopropoxyethoxy)methyl]phenol→Monoisopropylamine

Bisoprolol FumarateOptimised routesteps: 6total yield: /

Bisoprolol FumarateOptimised routesteps: 3total yield: /

Bisoprolol FumarateOptimised routesteps: 4total yield: /

Bisoprolol FumarateOptimised routesteps: 4total yield: 5.57g(Bisoprolol-030)

Belotecan HydrochlorideOriginator routesteps: 4total yield: /

1-(2-nitrophenyl)ethan-1-one→propan-2-amine→benzyl isopropyl(3-(2-nitrophenyl)-3-oxopropyl)carbamate→benzyl (3-(2-aminophenyl)-3-oxopropyl)(isopropyl)carbamate→(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione→benzyl (S)-(2-(4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl)ethyl)(isopropyl)carbamate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2,4-Dichloro-5-fluoropyrimidine Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.