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CAS 7531-52-4
(S)-pyrrolidine-2-carboxamide
Codes: ALPE-011, VILD-001
Application context (from source-drug indications)
Growth disorderAlpelisibGenetic diseaseAlpelisibPIK3CA-related overgrowth spectrumAlpelisibBreast cancerAlpelisibType 2 diabetesVildagliptinSchizophreniaVildagliptinDyslipidaemiaVildagliptinInsulin resistanceVildagliptinType 1 diabetesVildagliptinDiabetesVildagliptin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Alpelisib | Tier C — Watch / trade | 2029 |
| Vildagliptin | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3,3,3-trifluoro-2,2-dimethylpropanoic acid→3,3,3-trifluoro-2,2-dimethylpropanoyl chloride→ethyl 3-oxo-3-((3-(trifluoromethyl)phenyl)amino)propanoate→2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4H-pyran-4-one→2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4(1H)-one→4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine→N-(4-methylthiazol-2-yl)acetamide→N-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)acetamide→4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine→N-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-imidazole-1-carboxamide→(S)-pyrrolidine-2-carboxamide
4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine→(S)-pyrrolidine-2-carboxamide→4-methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine→N-methoxy-N-methylacetamide→1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one→1-bromopyrrolidine-2,5-dione→4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine hydrobromide→phenyl (4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)carbamate
(S)-pyrrolidine-2-carboxamide→2-chloroacetyl chloride→(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxamide→N-(chloromethylene)-N-methylmethanaminium chloride→(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine→(1r,3s,5R,7S)-3-nitroadamantan-1-amine
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→tert-butyl ((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycinate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride
(S)-pyrrolidine-2-carboxamide→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride→tert-butyl ((3s,5s,7s)-adamantan-1-yl)glycinate→((3s,5s,7s)-adamantan-1-yl)glycine→tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→2-oxoacetic acid→N-formyl-N-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-1-(N-formyl-N-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carboxamide→(1R,3r,5R,7S)-3-(N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)formamido)adamantan-1-yl 2,2,2-trifluoroacetate→N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)-N-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)formamide
Intermediates available on this site
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