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CAS 754930-54-6
5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzenesulfonamide
Codes: Tamsulosin Hydrochloride-017
Application context (from source-drug indications)
Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-(2-bromopropanoyl)-2-methoxybenzenesulfonamide→benzyl[2-(2-ethoxyphenoxy)ethyl]amine→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}propanoyl)-2-methoxybenzenesulfonamide→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzene-1-sulfonamide→5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzenesulfonamide→5-(1-chloro-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 5total yield: 1.2g(Tamsulosin (Free))
5-(2-bromopropanoyl)-2-methoxybenzenesulfonamide→benzyl[2-(2-ethoxyphenoxy)ethyl]amine→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}propanoyl)-2-methoxybenzenesulfonamide→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzene-1-sulfonamide→5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzenesulfonamide→5-(1-chloro-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide
5-(2-bromopropanoyl)-2-methoxybenzenesulfonamide→benzyl[2-(2-ethoxyphenoxy)ethyl]amine→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}propanoyl)-2-methoxybenzenesulfonamide→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzene-1-sulfonamide→5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzenesulfonamide→5-(1-chloro-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide
5-(2-bromopropanoyl)-2-methoxybenzenesulfonamide→benzyl[2-(2-ethoxyphenoxy)ethyl]amine→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}propanoyl)-2-methoxybenzenesulfonamide→5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzene-1-sulfonamide→5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzenesulfonamide→5-(1-chloro-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide
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