CAS 7580-85-0

2-(tert-butoxy)ethanol

Codes: MACI-020, BOSE-015

Application context (from source-drug indications)

Pulmonary arterial hypertensionMacitentanPulmonary hypertensionMacitentanChronic diseaseMacitentanChronic thromboembolic pulmonary hypertensionMacitentanThromboembolismMacitentanAngina pectorisMacitentan溃疡Bosentan HydratePulmonary arterial hypertensionBosentan HydratePulmonary hypertensionBosentan HydrateSystemic sclerosisBosentan Hydrate冠状血管痉挛Bosentan Hydrate大动脉炎Bosentan Hydrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Macitentan	Tier B — Position early	-
Bosentan Hydrate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

MacitentanOptimised routesteps: 4total yield: 225 g

5-(4-bromophenyl)-4,6-dichloropyrimidine→MACI-009→MACI-011→5-bromo-2-chloropyrimidine→sulfurisocyanatidic chloride→propan-1-amine→MACI-019→2-(tert-butoxy)ethanol

Bosentan HydrateProcess routesteps: 5total yield: 214.47 g

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione→potassium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide→2-(tert-butoxy)ethanol→N-(6-(2-(tert-butoxy)ethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(tert-butyl)benzenesulfonamide→2-((6-((4-(tert-butyl)phenyl)sulfonamido)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethyl formate

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