CAS 760-94-1

dimethyl 2-bromopentanedioate

Codes: LENA-010

Application context (from source-drug indications)

Marginal zone B-cell lymphomaLenalidomideFollicular lymphomaLenalidomideAdult T-cell leukaemia/lymphomaLenalidomideMantle cell lymphomaLenalidomideMyelodysplastic syndromeLenalidomideMultiple myelomaLenalidomide

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Lenalidomide	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LenalidomideOptimised routesteps: 5total yield: 1.12 g

methyl 2-(bromomethyl)-3-nitrobenzoate→4-nitroisoindolin-1-one→4-aminoisoindolin-1-one→dimethyl 2-bromopentanedioate→dimethyl 2-(4-amino-1-oxoisoindolin-2-yl)pentanedioate→glutaric acid

LenalidomideOptimised routesteps: 4total yield: 5.6 g

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione→4-nitroisoindolin-1-one→dimethyl 2-bromopentanedioate→dimethyl 2-(4-nitro-1-oxoisoindolin-2-yl)pentanedioate→methyl 5-amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	methyl 2-(bromomethyl)-3-nitrobenzoate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	3-aminopiperidine-2,6-dione hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—

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