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CAS 761423-01-2
(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
Codes: IPRA-008
Application context (from source-drug indications)
Type 2 diabetesSitagliptin Phosphate Monohydrate/Ipragliflozin L-ProlineType 2 diabetesIpragliflozin L-ProlineType 1 diabetesIpragliflozin L-ProlineDiabetesIpragliflozin L-ProlineLiver diseaseIpragliflozin L-Proline
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | Tier C — Watch / trade | - |
| Ipragliflozin L-Proline | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methoxy)(tert-butyl)dimethylsilane→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl((tert-butyldimethylsilyl)oxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl(hydroxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran→2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methoxy)(tert-butyl)dimethylsilane→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl((tert-butyldimethylsilyl)oxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl(hydroxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran→2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
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