← Back to patent-cliff list
CAS 761440-75-9
2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline
Codes: Conteltinib-013
Application context (from source-drug indications)
Non-small cell lung cancerConteltinibSolid tumourConteltinibPancreatic cancerConteltinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactate | Tier C — Watch / trade | - |
| Conteltinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateOriginator routesteps: 11total yield: 685 g
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-Methoxy-4-[4-(4-methylpiperazin -1-yl)piperidin-1-yl]aniline Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.