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CAS 7623-09-8
1,2 Dichloro-1-propanone2-Chloropropanoyl chloride
Codes: (IIa)461018-13-a, Ephedrine Sulfate-002
Application context (from source-drug indications)
Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibHypotensionEphedrine Sulfate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibrutinib | Tier A — Act now | 2027 |
| Ephedrine Sulfate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1,2 Dichloro-1-propanone→2-Bromopropanoyl bromide→1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-chloropropan-1-one→1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-bromopropan-1-one
Benzene→2-Chloropropanoyl chloride→2-Chloro-1-phenylpropan-1-one→alpha-Bromopropiophenone→Methylamine→2-(Methylamino)-1-phenylpropan-1-one→(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid (2S)-2-(methylamino)-1-phenylpropan-1-one (1/2)→(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol (1/2)→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol hydrochloride→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol
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