CAS 763114-26-7

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Codes: OLAP-006, FLUZO-001

Application context (from source-drug indications)

Endometrial cancerOlaparibCastration-resistant prostate cancerOlaparibProstate cancerOlaparibPeritoneal cancerOlaparibEpithelial ovarian cancerOlaparibFallopian tube cancerOlaparibBreast cancerFluzoparibPeritoneal cancerFluzoparibOvarian cancerFluzoparibFallopian tube cancerFluzoparibProstate cancerFluzoparib三阴性乳腺癌Fluzoparib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Olaparib	Tier A — Act now	2028
Fluzoparib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

OlaparibOriginator routesteps: 6total yield: 1.27 kg

3-hydroxyisobenzofuran-1(3H)-one→dimethyl phosphonate→dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazine-1-carboxylate→4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one→cyclopropanecarbonyl chloride

OlaparibOptimised routesteps: 6total yield: 8.67 g

3-hydroxyisobenzofuran-1(3H)-one→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→cyclopropanecarbonyl chloride→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile→cyclopropyl(piperazin-1-yl)methanone hydrochloride→piperazine

FluzoparibOriginator routesteps: 1total yield: 205 mg (Fluzoparib)

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine→Fluzoparib

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	2-fluoro-5-((4-oxo-3,4-dihydrophthalazin -1-yl)Methyl)benzoic acid Pharmaceutical Intermediates	On request	On request	On request	—

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