CAS 77-78-1

Dimethoxysulfone

Codes: (XXXIII)638294-1-d, (XXII)1225102-2-b

Application context (from source-drug indications)

Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneNon-small cell lung cancerFulzerasibColorectal cancerFulzerasibSolid tumourFulzerasib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Finerenone	Tier C — Watch / trade	2030
Fulzerasib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

FinerenoneOptimised routesteps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

FulzerasibOptimised routesteps: 9total yield: /

(aR)-6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-1,8-naphthyridin-2-one→6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-1,8-naphthyridin-2-one→(R)-Piperazine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl diester→(aR)-6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-3-nitro-1,8-naphthyridin-2-one→(aR)-6,7-Dichloro-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl trifluoromethanesulfonate→(aR)-1-tert-Butyl 3-methyl (3R)-4-[6,7-dichloro-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]piperazine-1,3-dicarboxylate→(aR)-tert-Butyl (4aR)-10,11-dichloro-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→Dimethoxysulfone→(aR)-tert-Butyl (4aR)-10,11-dichloro-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→(2-Fluoro-6-hydroxyphenyl)boronic acid→(aR)-tert-Butyl (4aR)-11-chloro-10-(2-fluoro-6-hydroxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→(aR)-(4aR)-11-Chloro-10-(2-fluoro-6-hydroxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-5,7-dione→2-Propenoyl chloride

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	On request	On request	On request	—

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