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CAS 78727-16-9
N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Codes: TOFA-032
Application context (from source-drug indications)
Ankylosing spondylitisTofacitinib CitrateJuvenile rheumatoid arthritisTofacitinib CitrateUlcerative colitisTofacitinib CitratePsoriatic arthritisTofacitinib CitrateRheumatoid arthritisTofacitinib Citrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tofacitinib Citrate | Tier B — Position early | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-(1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-cyanoacetyl chloride→4-methylpyridine→1-benzyl-4-methyl-1,2,3,6-tetrahydropyridine→(3S,4R)-1-benzyl-4-methylpiperidin-3-ol→N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | （3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCL Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 1-benzyl-4-methylpiperidin-3-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.