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CAS 791778-53-5
(1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine
Codes: CARI-007, CARI-021
Application context (from source-drug indications)
Major depressive disorderCariprazine HydrochlorideSchizophreniaCariprazine HydrochlorideManiaCariprazine Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cariprazine Hydrochloride | Tier A — Act now | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-bromo-2,3-dichlorobenzene→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(2,3-dichlorophenyl)piperazine-1-carboxylate→1-(2,3-dichlorophenyl)piperazine hydrochloride→tert-butyl ((1r,4r)-4-(2-oxoethyl)cyclohexyl)carbamate→tert-butyl ((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)carbamate→(1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine→dimethylcarbamic chloride
tert-butyl ((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)carbamate→1-(2,3-dichlorophenyl)piperazine→2-(4-nitrophenyl)acetic acid→ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride→ethyl 2-((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)acetate→tert-butyl ((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)carbamate→(1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine→N-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1H-imidazole-1-carboxamide
Intermediates available on this site
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