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CAS 79265-30-8
2-(trimethylsilyl)-1,3-thiazole
Codes: (V)101438-19-a, (V)140605-2-a
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateBladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Pancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelNon-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-(+)-2-Phenylglycine→L-Phenylglycine methyl ester→methyl (2S)-2-phenyl-2-(phenylformamido)acetate→N-[(1S)-2-oxo-1-phenylethyl]benzamide→(4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carbaldehyde→2-(trimethylsilyl)-1,3-thiazole→N-[(1S,2R)-2-hydroxy-1-phenyl-2-(1,3-thiazol-2-yl)ethyl]benzamide→1-Methoxy-1-methylethyl methyl ether→(4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-5-(1,3-thiazol-2-yl)-1,3-oxazolidine→(4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid→alpha-Chlorobenzaldehyde
(S)-(+)-2-Phenylglycine→Methyl trifluoromethanesulfonate→Bis(1,1-dimethylethyl) dicarbonoate→(S)-N-Boc-phenylglycine methyl ester→N-(tert-Butoxycarbonyl)-L-2-phenylglycinal→2-(trimethylsilyl)-1,3-thiazole→tert-butyl N-[(1S,2R)-2-hydroxy-1-phenyl-2-(1,3-thiazol-2-yl)ethyl]carbamate→1-Methoxy-1-methylethyl methyl ether→tert-butyl (4S,5R)-2,2-dimethyl-4-phenyl-5-(1,3-thiazol-2-yl)-1,3-oxazolidine-3-carboxylate→tert-butyl (4S,5R)-5-formyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3-carboxylate→(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid
(S)-(+)-2-Phenylglycine→L-Phenylglycine methyl ester→methyl (2S)-2-phenyl-2-(phenylformamido)acetate→N-[(1S)-2-oxo-1-phenylethyl]benzamide→(4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carbaldehyde→2-(trimethylsilyl)-1,3-thiazole→N-[(1S,2R)-2-hydroxy-1-phenyl-2-(1,3-thiazol-2-yl)ethyl]benzamide→1-Methoxy-1-methylethyl methyl ether→(4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-5-(1,3-thiazol-2-yl)-1,3-oxazolidine→(4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid→alpha-Chlorobenzaldehyde
(S)-(+)-2-Phenylglycine→1,1,1,-Trifluoromethanesulfonic acid methyl ester→Bis(1,1-dimethylethyl) dicarbonoate→(S)-N-Boc-phenylglycine methyl ester→N-(tert-Butoxycarbonyl)-L-2-phenylglycinal→2-(trimethylsilyl)-1,3-thiazole→tert-butyl N-[(1S,2R)-2-hydroxy-1-phenyl-2-(1,3-thiazol-2-yl)ethyl]carbamate→1-Methoxy-1-methylethyl methyl ether→tert-butyl (4S,5R)-2,2-dimethyl-4-phenyl-5-(1,3-thiazol-2-yl)-1,3-oxazolidine-3-carboxylate→tert-butyl (4S,5R)-5-formyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3-carboxylate→(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid
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