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CAS 79902-59-3
(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Codes: (III)122234-5-a
Application context (from source-drug indications)
DyslipidaemiaFenofibrate/SimvastatinHyperlipidaemiaFenofibrate/SimvastatinCardiac and vascular disordersFenofibrate/SimvastatinHypercholesterolaemiaFenofibrate/SimvastatinHyperlipidaemiaSimvastatinMyocardial infarctionSimvastatinDyslipidaemiaSimvastatinHeterozygous familial hypercholesterolaemiaSimvastatinStrokeSimvastatinHypercholesterolaemiaSimvastatin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fenofibrate/Simvastatin | Tier C — Watch / trade | - |
| Simvastatin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4R,6R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]oxan-2-one→2,2-dimethylbutanoic acid→(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
(4R,6R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]oxan-2-one→2,2-dimethylbutanoic acid→(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Intermediates available on this site
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