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CAS 80-48-8

4-Methylbenzenesulfonic acid methyl ester

Codes: (VI)860865-1-a

Application context (from source-drug indications)

HyperhidrosisGlycopyrrolate TosylateChronic obstructive pulmonary diseaseGlycopyrrolate TosylateAsthmaGlycopyrrolate TosylateChronic obstructive pulmonary diseaseFormoterol Fumarate/Glycopyrrolate

Source drugs (routes using this intermediate)

DrugTierExpiry
Glycopyrrolate TosylateTier C — Watch / trade-
Formoterol Fumarate/GlycopyrrolateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Glycopyrrolate TosylateOptimised routesteps: 4total yield: /
(+/-)-Cyclopentylmandelic acid→2-Cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone→1-Methylpyrrolidin-3-ol→(1-Methylpyrrolidin-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate→(3R)-1-Methylpyrrolidin-3-yl (2S)-cyclopentyl(hydroxy)phenylacetate→4-Methylbenzenesulfonic acid methyl ester
Formoterol Fumarate/GlycopyrrolateOptimised routesteps: 4total yield: /
(+/-)-Cyclopentylmandelic acid→2-Cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone→1-Methylpyrrolidin-3-ol→(1-Methylpyrrolidin-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate→(3R)-1-Methylpyrrolidin-3-yl (2S)-cyclopentyl(hydroxy)phenylacetate→4-Methylbenzenesulfonic acid methyl ester

Intermediates available on this site

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