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CAS 802541-49-7
(Z)-ethyl 6-((dimethylamino)methylene)-1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate
Codes: PHA-848125-007
Application context (from source-drug indications)
Non-small cell lung cancerMilciclib maleate胸腺瘤Milciclib maleateHepatocellular carcinomaMilciclib maleateSolid tumourMilciclib maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Milciclib maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(Z)-ethyl 6-((dimethylamino)methylene)-1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→guanidine hydrochloride→ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→isopentyl nitrite→ethyl 8-iodo-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→8-iodo-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid→5,5-dimethylcyclohexane-1,3-dione→3-methoxy-5,5-dimethylcyclohex-2-enone→4,4-dimethyl-7-oxabicyclo[4.1.0]heptan-2-one→2-methoxy-5,5-dimethylcyclohex-2-enone→ethyl 1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→1,1-di-tert-butoxy-N,N-dimethylmethanamine→8-iodo-N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide→4-(4-methylpiperazin-1-yl)aniline
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