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CAS 82961-76-0
methyl 4-(benzyloxy)-3-oxobutanoate
Codes: DOLU-036
Application context (from source-drug indications)
HIV infectionDolutegravir SodiumLabour and deliveryDolutegravir SodiumMycobacterium tuberculosis infectionDolutegravir SodiumHepatitisDolutegravir SodiumHerpesvirus infectionDolutegravir SodiumHepatic function declineDolutegravir Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dolutegravir Sodium | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2,4-difluorophenyl)methanamine→(R)-3-aminobutan-1-ol→(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide→methyl 4-chloro-3-oxobutanoate→methyl 4-(benzyloxy)-3-oxobutanoate→(Z)-methyl 4-(benzyloxy)-2-((dimethylamino)methylene)-3-oxobutanoate→dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate→2,2-dimethoxyethanamine→dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate
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