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CAS 84803-57-6
(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile
Codes: Xylometazoline Hydrochloride-006
Application context (from source-drug indications)
Nasal congestionXylometazoline HydrochlorideRhinitisXylometazoline HydrochlorideCommon coldXylometazoline Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dexpanthenol/Xylometazoline Hydrochloride | Tier C — Watch / trade | - |
| Xylometazoline Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dexpanthenol/Xylometazoline HydrochlorideOptimised routesteps: 5total yield: 12.4g(Xylometazoline Hydrochloride (API))
1,3-Dimethylbenzene→1,1-Dimethylethanol→1-tert-Butyl-3,5-dimethylbenzene→1-Chloro-1-methoxymethane→5-tert-Butyl-2-(chloromethyl)-1,3-dimethylbenzene→(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole 4-methylbenzenesulfonate
Xylometazoline HydrochlorideOptimised routesteps: 5total yield: 12.4g(Xylometazoline Hydrochloride (API))
1,3-Dimethylbenzene→1,1-Dimethylethanol→1-tert-Butyl-3,5-dimethylbenzene→1-Chloro-1-methoxymethane→5-tert-Butyl-2-(chloromethyl)-1,3-dimethylbenzene→(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole 4-methylbenzenesulfonate
Intermediates available on this site
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