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CAS 848139-78-6
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Codes: NERT-011
Application context (from source-drug indications)
Breast cancerNeratinib Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Neratinib Maleate | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-chloro-4-(pyridin-2-ylmethoxy)aniline→2-chloro-4-nitrophenol→pyridin-2-ylmethanol→2-((2-chloro-4-nitrophenoxy)methyl)pyridine→N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide→N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide→6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile→(E)-4-(dimethylamino)but-2-enoic acid hydrochloride
2-((2-chloro-4-nitrophenoxy)methyl)pyridine→N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide→N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide→6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile→(E)-4-(dimethylamino)but-2-enoic acid hydrochloride→2-amino-5-nitrophenol→N-(2-hydroxy-4-nitrophenyl)acetamide→N-(2-ethoxy-4-nitrophenyl)acetamide→N-(4-amino-2-ethoxyphenyl)acetamide→ethyl (Z)-2-cyano-3-ethoxyacrylate→(Z)-ethyl 3-((4-acetamido-3-ethoxyphenyl)amino)-2-cyanoacrylate→N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino) -7- ethoxyquinoline-3-carbonitrile Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.