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CAS 85-44-9
isobenzofuran-1,3-dione2-Benzofuran-1,3-dionePhthalic anhydride
Codes: LINA-015, TREL-014, ALOG-024, Ambroxol- 034, AMRU-006, Cefonicid-002
Application context (from source-drug indications)
Type 2 diabetesLinagliptinType 2 diabetesTrelagliptin SuccinateDiabetesTrelagliptin SuccinateType 2 diabetesAlogliptin BenzoateDiabetesAlogliptin BenzoateAcute coronary syndromeAlogliptin BenzoateChronic bronchitisRoxithromycin/Ambroxol HydrochlorideBronchitisRoxithromycin/Ambroxol HydrochlorideRespiratory tract infectionRoxithromycin/Ambroxol HydrochloridePneumoniaRoxithromycin/Ambroxol HydrochlorideTracheitisRoxithromycin/Ambroxol HydrochlorideBacterial infectionRoxithromycin/Ambroxol HydrochlorideAnaesthesiaAmbroxol HydrochloridePharyngitisAmbroxol HydrochlorideRespiratory diseaseAmbroxol HydrochlorideBronchitisAmbroxol HydrochlorideParkinson's diseaseAmbroxol HydrochlorideParkinsonismAmbroxol HydrochlorideNon-small cell lung cancerAmrubicin HydrochlorideSmall cell lung cancerAmrubicin HydrochlorideLung cancerAmrubicin HydrochlorideSarcomaAmrubicin HydrochlorideMetastatic breast cancerAmrubicin HydrochlorideSolid tumourAmrubicin HydrochlorideBacterial infectionCefonicid Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Linagliptin | Tier C — Watch / trade | 2029 |
| Trelagliptin Succinate | Tier C — Watch / trade | - |
| Alogliptin Benzoate | Tier C — Watch / trade | - |
| Roxithromycin/Ambroxol Hydrochloride | Tier C — Watch / trade | - |
| Ambroxol Hydrochloride | Tier C — Watch / trade | - |
| Amrubicin Hydrochloride | Tier C — Watch / trade | - |
| Cefonicid Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→1-(2-aminophenyl)ethan-1-one→2-chloroacetonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione (2S,3S)-2,3-dihydroxysuccinate→(R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→pyridin-3-amine→piperidin-3-amine→isobenzofuran-1,3-dione→2-(piperidin-3-yl)isoindoline-1,3-dione→(2S,3S)-2,3-dihydroxysuccinic acid
2-(bromomethyl)-4-fluorobenzonitrile→6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→(R)-piperidin-3-amine→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→isobenzofuran-1,3-dione
6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→(R)-tert-butyl (1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl)carbamate→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-piperidin-3-amine dihydrochloride→isobenzofuran-1,3-dione
5,8-dimethoxy-3,4-dihydronaphthalen-2(1H)-one→2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid→methyl (R)-2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate→(R)-1-(2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethan-1-one→(R)-N-(2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide→isobenzofuran-1,3-dione→(R)-N-(2-acetyl-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)acetamide→(R)-N-(5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)acetamide→(1S,5S)-7,14-dihydroxy-3-methyl-5-(2-methyl-1,3-dioxolan-2-yl)-5,6-dihydro-1H-1,5-methanoanthra[2,3-f][1,3]oxazocine-8,13-dione→(7S,9S)-9-acetyl-9-amino-6,7,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione→AMRU-011→AMRU-012
aminomethanesulfonic acid→Phthalic anhydride→(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methanesulfonic acid→(1,3-dioxoisoindol-2-yl)methanesulfonyl chloride→(5-sulfanyl-1H-1,2,3,4-tetrazol-1-yl)methanesulfonic acid→N-tert-butyl-1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methanesulfonamide→1-amino-N-tert-butylmethanesulfonamide→N-tert-butyl-1-{[(methylsulfanyl)methanethioyl]amino}methanesulfonamide→N-tert-butyl-1-(5-sulfanyl-1H-1,2,3,4-tetrazol-1-yl)methanesulfonamide→{[(methylsulfanyl)methanethioyl]amino}methanesulfonic acid→(6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid→(6R,7R)-7-Amino-8-oxo-3-([[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl]methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid→(1R)-2-Chloro-2-oxo-1-phenylethyl dichloroacetate→(6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid→Formic acid 2-chloro-2-oxo-1(R)-phenylethyl ester<-fgf->O-Formyl-D-mandelic acid chloride<-fgf->D-O-Formylmandeolyl chloride
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 3-Methylxanthine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 8-Bromo-3-methyl-3,9-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-(Chloromethyl)-4-methylquinazoline Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 8-Bromo-7-(but-2-yn-1-yl)-3-methy1-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | [(3R)-1-[7-(2-Butynyl)-2,3,6,7-tetrahydro-3-methy1-1-[(4-methy1-2-quinazolinyl)methyl]-2,6-dioxo-1H-purin-8-yll-3-piperidinyllcarbamicacid 1,1-dimethylethyl ester Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.