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CAS 85031-59-0

Dihydroartemisinic acid

Codes: (I)91299-1-a

Application context (from source-drug indications)

Plasmodium infectionArtesunate/Pyronaridine PhosphateCOVID-19Artesunate/Pyronaridine PhosphateFalciparum malariaArtesunate/Pyronaridine PhosphatePlasmodium infectionArtesunate/Mefloquine HydrochlorideFalciparum malariaArtesunate/Mefloquine HydrochloridePlasmodium infectionArtesunateIntestinal neoplasmArtesunateColon cancerArtesunateCervical intraepithelial neoplasiaArtesunateHIV infectionArtesunateCervical cancerArtesunate

Source drugs (routes using this intermediate)

DrugTierExpiry
Artesunate/Pyronaridine PhosphateTier C — Watch / trade-
Artesunate/Mefloquine HydrochlorideTier C — Watch / trade-
ArtesunateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Artesunate/Pyronaridine PhosphateOptimised routesteps: 3total yield: /
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran
Artesunate/Mefloquine HydrochlorideOptimised routesteps: 3total yield: /
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran
ArtesunateOptimised routesteps: 3total yield: /
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.