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CAS 857762-32-4
6-Bromo-3-chloroquinolin-4-ol
Codes: (II)1055986-1-a
Application context (from source-drug indications)
AcromegalyPaltusotineIntestinal neoplasmPaltusotine恶性类癌综合征PaltusotineDiarrhoeaPaltusotineLiver cancerPaltusotine回肠肿瘤Paltusotine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paltusotine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-Bromoquinolin-4-ol→6-Bromo-3-chloroquinolin-4-ol→4,6-Dibromo-3-chloroquinoline→1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→6-Bromo-4-chloroquinoline→N-Boc-1-(6-bromoquinolin-4-yl)piperidin-4-amine→2-Hydroxy-3-cyano-potassium phenyltrifluoro borate→(3-Cyano-2-hydroxyphenyl)boronic acid→N-Boc-3-[4-(4-aminopiperidin-1-yl)-3-chloroquinolin-6-yl]-2-hydroxybenzonitrile→(3,5-Difluorophenyl)Boranediol→N-Boc-1-(6-(3-cyano-2-hydroxyphenyl)-3-(3,5-difluorophenyl)quinolin-4-yl)piperidin-4-amine→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile dihydrogen chloride→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→2-Bromo-6-cyanophenol→3-Bromo-2-(methoxymethoxy)benzonitrile
Intermediates available on this site
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