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CAS 861718-85-6
(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal
Codes: EFIN-015, VORI-018
Application context (from source-drug indications)
OnychomycosisEfinaconazoleFungal infectionVoriconazoleCandidaemiaVoriconazoleCandidiasisVoriconazoleAspergillus infectionVoriconazole新型隐球菌感染Voriconazole镰刀菌感染Voriconazole
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Efinaconazole | Tier C — Watch / trade | - |
| Voriconazole | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1H-1,2,4-triazole→1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole→2-chloro-1-(2,4-difluorophenyl)ethan-1-one→trimethylsilanecarbonitrile→(((2S,3S,4R)-4-(4,5-difluoro-2-hydroxyphenoxy)-3-hydroxytetrahydro-2H-pyran-2-yl)methyl)diphenylphosphine oxide→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal→(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol→4-methylenepiperidine
2-chloro-1-(2,4-difluorophenyl)ethan-1-one→(((2S,3S,4R)-4-(4,5-difluoro-2-hydroxyphenoxy)-3-hydroxytetrahydro-2H-pyran-2-yl)methyl)diphenylphosphine oxide→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal→4-bromo-5-fluoropyrimidine→(R)-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanol→(R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanone→methyltriphenylphosphonium bromide→(R)-4-(1-(2-(2,4-difluorophenyl)oxiran-2-yl)vinyl)-5-fluoropyrimidine→4-((S)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine→1H-1,2,4-triazole
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