(4-methoxy-3,5-dimethylpyridin-2-yl)methanol (86604-78-6) intermediate

Application context (from source-drug indications)

Helicobacter pylori infectionAmoxicillin/Omeprazole/RifabutinDyspepsiaAmoxicillin/Omeprazole/RifabutinGastric ulcerCinitapride Tartrate/OmeprazoleGastro-oesophageal reflux diseaseCinitapride Tartrate/OmeprazoleDyspepsiaCinitapride Tartrate/OmeprazoleHeartburnOmeprazoleGastro-oesophageal reflux diseaseOmeprazoleGastric ulcerOmeprazoleHyperacidityOmeprazoleDuodenal ulcerOmeprazoleHelicobacter pylori infectionOmeprazoleHeartburnEsomeprazole Magnesium HydrateGastro-oesophageal reflux diseaseEsomeprazole Magnesium HydrateDuodenal ulcerEsomeprazole Magnesium HydrateGastric ulcerEsomeprazole Magnesium HydratePeptic oesophagitisEsomeprazole Magnesium HydrateHelicobacter pylori infectionEsomeprazole Magnesium Hydrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Amoxicillin/Omeprazole/Rifabutin	Tier C — Watch / trade	-
Cinitapride Tartrate/Omeprazole	Tier C — Watch / trade	-
Omeprazole	Tier C — Watch / trade	-
Esomeprazole Magnesium Hydrate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Amoxicillin/Omeprazole/RifabutinOptimised routesteps: 3total yield: /

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-imidazo[4,5-b]pyridine→5-methoxy-1H-benzo[d]imidazole-2-thiol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole→3-chlorobenzoperoxoic acid→Omeprazole

Cinitapride Tartrate/OmeprazoleOptimised routesteps: 3total yield: /

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-imidazo[4,5-b]pyridine→5-methoxy-1H-benzo[d]imidazole-2-thiol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole→3-chlorobenzoperoxoic acid→Omeprazole

OmeprazoleOptimised routesteps: 3total yield: /

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-imidazo[4,5-b]pyridine→5-methoxy-1H-benzo[d]imidazole-2-thiol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole→3-chlorobenzoperoxoic acid→Omeprazole

Esomeprazole Magnesium HydrateOptimised routesteps: 6total yield: 418.00 mg

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol→2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine→5-methoxy-1H-benzo[d]imidazole-2-thiol→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole→5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole→(S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole→sodium (S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Intermediates available on this site

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