CAS 86639-52-3

(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Codes: FIRT-001

Application context (from source-drug indications)

Colorectal cancerFirtecan pegolBreast cancerFirtecan pegolSolid tumourFirtecan pegolMetastatic breast cancerFirtecan pegolLymphomaFirtecan pegol

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Firtecan pegol	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Firtecan pegolOriginator routesteps: 7total yield: 0.86 g (Firtecan pegol)

(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→2-((tert-butoxycarbonyl)amino)acetic acid→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl (tert-butoxycarbonyl)glycinate→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl glycinate hydrochloride→tert-butyl 2-bromoacetate→7,7'-(oxybis(methylene))bis(3,6,9,12-tetraoxatetradecanedioic acid)→tetrakis((S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) 10,10'-(oxybis(methylene))bis(4,17-dioxo-6,9,12,15-tetraoxa-3,18-diazaicosanedioate)→2,2',2'',2'''-((oxybis(propane-3,1,2-triyl))tetrakis(oxy))tetrakis(ethan-1-ol)→tetra-tert-butyl 7,7'-(oxybis(methylene))bis(3,6,9,12-tetraoxatetradecanedioate)

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	7-Ethyl-10-hydroxycamptothecin Pharmaceutical Intermediates	On request	On request	On request	—

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